The IRB/IEC should make decisions at announced meetings when at least a quorum of people are present, as stipulated in its written operating procedures. Advance in your career by receiving the best training in clinical investigations from experts with years of industry experience and extensive knowledge of the ICH GCP guidelines. When it's not practical to have a proper IB, the sponsor-investigator must supply an enlarged background information element instead. The host shouldn't have management of these data. 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